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Consequently, only the Monarch E study’s experimental group demonstrates an absolute benefit of 7.6% in 5-year invasive disease-free survival (iDFS), whereas the PALLAS and PENELOPE-B trials do not achieve their primary end points

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Oral administration of allicin to mice lowered ROS production and prevented ROS-induced cardiac hypertrophy by inhibiting pro-inflammatory pathways like mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase 3β (GSK3β) signaling pathways (20)